Luxury European Wellness & Concierge Pharmacy Care

OSTENIL® PLUS 40 mg/2 mL is a sterile, single-use intra-articular injection containing sodium hyaluronate (hyaluronic acid). It is designed to help relieve joint pain and restricted mobility associated with degenerative and traumatic changes of synovial joints, particularly osteoarthritis.

Each 2 mL prefilled syringe contains 40 mg sodium hyaluronate, providing a concentration of 20 mg/mL (2%).

OSTENIL PLUS also contains mannitol, which helps stabilize the hyaluronate molecules and is a distinguishing feature of the PLUS formulation.

Key Benefits & Features

• Contains 40 mg sodium hyaluronate per 2 mL syringe
• High concentration: 20 mg/mL (2%)
• Designed for intra-articular injection
• Helps relieve pain associated with osteoarthritis and degenerative joint changes
• Helps improve joint mobility
• Supports lubrication and shock-absorbing properties of synovial fluid
• Contains mannitol to help stabilize hyaluronic acid
• Sterile, ready-to-use prefilled syringe
• Single-use medical device
• 1 prefilled syringe per package

Active Component

Each 2 mL Prefilled Syringe Contains:

Sodium Hyaluronate – 40 mg

Equivalent to:

20 mg/mL sodium hyaluronate (2%)

The sodium hyaluronate is produced by bacterial fermentation.

Other Components

The solution also contains:

• Mannitol
• Sodium chloride
• Disodium phosphate
• Sodium dihydrogen phosphate
• Water for injection

What Is Sodium Hyaluronate?

Sodium hyaluronate is a form of hyaluronic acid, a substance naturally present in synovial fluid.

Healthy synovial fluid helps:

• Lubricate joint surfaces
• Reduce friction during movement
• Absorb mechanical shock
• Support smooth and comfortable joint movement

In osteoarthritis and other degenerative joint conditions, the quality and viscoelastic properties of synovial fluid may deteriorate. Intra-articular hyaluronic acid products such as OSTENIL PLUS are designed to supplement the synovial environment.

Uses

OSTENIL PLUS is intended for the treatment of pain and restricted mobility associated with degenerative and traumatic changes in synovial joints, including osteoarthritis.

It may be used in joints such as the:

• Knee
• Hip
• Shoulder
• Ankle
• Other synovial joints when clinically appropriate

Directions for Use

For intra-articular injection only.

OSTENIL PLUS must be administered by a qualified healthcare professional experienced in intra-articular injections.

The manufacturer's treatment regimen generally consists of one injection into the affected joint. When clinically necessary, treatment may be repeated according to the product instructions and healthcare professional's assessment.

The syringe is intended for single use only.

OSTENIL PLUS vs. Regular OSTENIL

OSTENIL PLUS provides a higher concentration of sodium hyaluronate than standard OSTENIL formulations.

OSTENIL PLUS:

• 40 mg sodium hyaluronate
• 2 mL syringe
• 20 mg/mL
• Contains mannitol

This makes it important to list the product specifically as OSTENIL PLUS 40 mg/2 mL rather than simply OSTENIL.

Product Details

Brand: OSTENIL® PLUS
Product Type: Intra-Articular Hyaluronic Acid Injection
Active Component: Sodium Hyaluronate
Strength: 40 mg/2 mL
Concentration: 20 mg/mL (2%)
Syringe Volume: 2 mL
Pack Size: 1 Prefilled Syringe
Administration: Intra-Articular
Sterility: Sterile
Use: Single Use
Manufacturer: TRB Chemedica

Important Information

OSTENIL PLUS is not intended for self-injection.

Intra-articular injection requires appropriate anatomical knowledge, aseptic technique, and professional assessment of the affected joint.

Treatment decisions should be made by a healthcare professional based on the patient's diagnosis, symptoms, and individual clinical circumstances.

Warnings

• For intra-articular injection only.
• Administration must be performed by a qualified healthcare professional.
• Do not use if the prefilled syringe or sterile packaging is damaged.
• Do not use after the expiration date.
• Do not reuse the syringe.
• Do not resterilize.
• Do not use in patients with known hypersensitivity to any component.
• Injection should not be performed through infected or significantly inflamed skin.
• Joint infection must be excluded when clinically suspected.
• Temporary local reactions such as pain, swelling, warmth, redness, or joint effusion may occur following intra-articular injection.
• Follow the complete manufacturer's instructions for use.

Storage

Store according to the manufacturer's instructions on the original packaging. Protect from conditions outside the specified storage range and do not freeze.

Keep the product in its original sterile packaging until ready for professional administration.

General Disclaimer

OSTENIL PLUS is a medical device intended for professional intra-articular administration. It is not intended for self-treatment. Diagnosis, suitability for treatment, injection technique, and follow-up should be determined by an appropriately qualified healthcare professional.