Longidaza® has multiple therapeutic effects:

• Proteolytic activity (breaks down connective tissue components)

• Anti-fibrotic (prevents or reduces scar tissue)

• Immunomodulatory, anti-inflammatory, and chelation-assisted

• Enhances drug bioavailability when used in combination therapy

• Medical Uses & Conditions Treated

  Suggested for use (in adults and adolescents over 12 years old) in conditions characterized by excessive connective tissue or fibrosis, including:

  • Gynecology: Prevents/treats adhesions after surgery or inflammation, aids in infertility due to tubal or endometrial issues, chronic endometritis

  • Urology: Chronic prostatitis, strictures, Peyronie’s disease, early-stage BPH, post-surgical scarring prevention

  • Dermatovenerology: Scleroderma, preventing fibrotic complications from STIs

  • Surgery: Prevent and treat abdominal adhesions, aid in wound healing

  • Pulmonology / TB: Helps with pulmonary fibrosis, interstitial pneumonia, pleuritis, tuberculosis fibrotic types

  • It can boost antibiotic effectiveness in relevant conditions

• Usage & Dosage Guidelines

  • Route: Rectal or vaginal (choose based on condition)

  • Frequency: Typically administered at night, once per application, after cleansing (for rectal use)

  • Course Length: Commonly 10–20 suppositories, with administration intervals varying by specialty:

    • Gynecology: every 2 days → 10 doses, plus potential maintenance

    • Urology: every other day → 20 total doses

    • Pulmonology: 1 dose every 2–4 days → total 10–20 doses

    • Dermatology: every 1–2 days → 10–15 doses

    • Surgery: every 2–3 days → 10 doses

  • Maintenance courses: Possible at 1 suppository every 5–7 days for 3–4 months; repeat after 3 months if needed

  • Note: Adolescents (12–18) should use rectal route only