Rumalon® Injection – 1 mL × 25 Ampoules | Glycosaminoglycan-Peptide Complex for Osteoarthritis & Joint Cartilage Disorders
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Description
Rumalon® (Румалон) is an intramuscular injectable medicine used for degenerative joint and cartilage disorders, including osteoarthritis of the knee and hip, interphalangeal osteoarthritis, spondylosis, spondyloarthrosis, meniscopathy, and chondromalacia of the patella.
Its active component is a glycosaminoglycan-peptide complex derived from calf costal cartilage and bone marrow. According to the official prescribing information, Rumalon affects cartilage metabolism by supporting the biosynthesis of sulfated mucopolysaccharides and collagen, stimulating articular-cartilage regeneration, and reducing catabolic processes in cartilage.
This presentation contains 25 single-dose ampoules of 1 mL each—the 1 mL × 25 format is specifically listed by the manufacturer and current drug references.
Key Benefits & Indications
Rumalon is indicated for degenerative-dystrophic joint conditions including:
- Gonarthrosis / knee osteoarthritis
- Coxarthrosis / hip osteoarthritis
- Interphalangeal joint osteoarthritis
- Spondylosis
- Spondyloarthrosis
- Meniscopathy
- Chondromalacia of the patella
Active Ingredient
Each 1 mL ampoule contains:
| Ingredient | Amount |
|---|---|
| Glycosaminoglycan-Peptide Complex from calf costal cartilage & bone marrow extracts | 2.25 mg |
The source extracts are derived from calf costal cartilage and bone marrow, in a ratio ranging from 1:2 to 1:4.
Other Ingredients
The extract formulation contains metacresol 2.60 mg, hydrochloric acid solution for pH adjustment, and water for injection.
How It Works
Rumalon is an animal-derived glycosaminoglycan-peptide preparation. According to the official prescribing information, it:
- Supports metabolism in hyaline cartilage
- Promotes biosynthesis of sulfated mucopolysaccharides
- Promotes collagen synthesis
- Stimulates regeneration of articular cartilage
- Reduces enzyme activity involved in cartilage degradation
- Helps inhibit catabolic processes in cartilage
Administration
For intramuscular (IM) administration only.
The official Russian prescribing information describes deep intramuscular administration beginning with smaller initial doses and progressing to 1 mL three times weekly over several weeks.
Product Details
Brand: Rumalon® / Румалон®
Active Ingredient: Glycosaminoglycan-Peptide Complex
Strength: 2.25 mg per 1 mL
Dosage Form: Solution for Intramuscular Injection
Ampoule Volume: 1 mL
Package Size: 25 Ampoules
Total Volume: 25 mL
Pharmacotherapeutic Group: Tissue Repair Stimulator
ATC Code: M09AX
Registration: Р N001330/01; current Russian reference also lists LP-№(013608)-(РГ-RU) dated February 18, 2026
Marketing Authorization Holder: C.O. Rompharm Company S.R.L.
Manufacturer: C.O. Rompharm Company S.R.L.
Country of Manufacture: Romania
Important Information
- Intended for intramuscular administration.
- Do not use in patients with hypersensitivity to the active ingredient or other components.
- Official information lists rheumatoid arthritis among contraindications.
- Contraindicated during pregnancy and breastfeeding due to insufficient safety information.
- Use in children is contraindicated/not established in the referenced prescribing information.
- Patients taking anticoagulants, antiplatelet drugs, or fibrinolytic medicines may require closer monitoring of coagulation parameters.
- Use only under the direction of a qualified healthcare professional.
Storage
Store at 2–25°C (36–77°F) and protect from light. Keep out of reach of children.