European Pharmacy & Wellness Products in the USA

Rumalon® (Румалон) is an intramuscular injectable medicine used for degenerative joint and cartilage disorders, including osteoarthritis of the knee and hip, interphalangeal osteoarthritis, spondylosis, spondyloarthrosis, meniscopathy, and chondromalacia of the patella.

Its active component is a glycosaminoglycan-peptide complex derived from calf costal cartilage and bone marrow. According to the official prescribing information, Rumalon affects cartilage metabolism by supporting the biosynthesis of sulfated mucopolysaccharides and collagen, stimulating articular-cartilage regeneration, and reducing catabolic processes in cartilage.

This presentation contains 25 single-dose ampoules of 1 mL each—the 1 mL × 25 format is specifically listed by the manufacturer and current drug references.

Key Benefits & Indications

Rumalon is indicated for degenerative-dystrophic joint conditions including:

• Gonarthrosis / knee osteoarthritis
• Coxarthrosis / hip osteoarthritis
• Interphalangeal joint osteoarthritis
• Spondylosis
• Spondyloarthrosis
• Meniscopathy
• Chondromalacia of the patella

Active Ingredient

Each 1 mL ampoule contains:

The source extracts are derived from calf costal cartilage and bone marrow, in a ratio ranging from 1:2 to 1:4.

Other Ingredients

The extract formulation contains metacresol 2.60 mg, hydrochloric acid solution for pH adjustment, and water for injection.

How It Works

Rumalon is an animal-derived glycosaminoglycan-peptide preparation. According to the official prescribing information, it:

• Supports metabolism in hyaline cartilage
• Promotes biosynthesis of sulfated mucopolysaccharides
• Promotes collagen synthesis
• Stimulates regeneration of articular cartilage
• Reduces enzyme activity involved in cartilage degradation
• Helps inhibit catabolic processes in cartilage

Administration

For intramuscular (IM) administration only.

The official Russian prescribing information describes deep intramuscular administration beginning with smaller initial doses and progressing to 1 mL three times weekly over several weeks.

Product Details

Brand: Rumalon® / Румалон®
Active Ingredient: Glycosaminoglycan-Peptide Complex
Strength: 2.25 mg per 1 mL
Dosage Form: Solution for Intramuscular Injection
Ampoule Volume: 1 mL
Package Size: 25 Ampoules
Total Volume: 25 mL
Pharmacotherapeutic Group: Tissue Repair Stimulator
ATC Code: M09AX
Registration: Р N001330/01; current Russian reference also lists LP-№(013608)-(РГ-RU) dated February 18, 2026
Marketing Authorization Holder: C.O. Rompharm Company S.R.L.
Manufacturer: C.O. Rompharm Company S.R.L.
Country of Manufacture: Romania

Important Information

• Intended for intramuscular administration.
• Do not use in patients with hypersensitivity to the active ingredient or other components.
• Official information lists rheumatoid arthritis among contraindications.
• Contraindicated during pregnancy and breastfeeding due to insufficient safety information.
• Use in children is contraindicated/not established in the referenced prescribing information.
• Patients taking anticoagulants, antiplatelet drugs, or fibrinolytic medicines may require closer monitoring of coagulation parameters.
• Use only under the direction of a qualified healthcare professional.

Storage

Store at 2–25°C (36–77°F) and protect from light. Keep out of reach of children.